Original β,γ-diamino acid as an inducer of a γ-turn mimic in short peptides.
نویسندگان
چکیده
Original αγα tripeptides containing one β,γ-diamino acid have been synthesized and their conformation determined by extensive NMR and molecular dynamic studies. These studies revealed the presence of a C(9) hydrogen bonded turn around the β,γ-diamino acid which was stabilized by bulky side chains of the preceding residue. This turn can be considered as a mimic of the well-known γ-turn.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 48 شماره
صفحات -
تاریخ انتشار 2012